Modification of medication action:

• Caffeine may increase the toxic effect of theophylline, methylphenidate (Nervousness, tremor, Insomnia)
• Tyramine, Dopamine or other vasoconstrictor in food enhance toxic effect of MAO inhibitor such as tranylcypromine (Hypertensive crisis which can be fatal)

Counteract with effect of drug:

• Vit K aids in production of clotting factors opposite to Warfarin.
• Caffeine is a stimulant which counteract the anti-anxiety effect of benzodiazepine.
• Immunosuppressant effect of drug like Azathioprine (Imuran) , cyclosporine (NE oral) may be blunted by immunostimulatory properties of natural products such as saw palmetto, echinacea.
• High fat diet counteracts the effect of anti-hyperlipidemic drug such as atorvastatin, fenofibrate, pravastatin.

Appetite changes:

• Cyproheptadine hydrochloride (periaxin) anti-histamine lead to marked increase in appetite.
• Anti-anxiety ( Diazepam, Alprazolam) lead to hyperphagia and excessive eating.
• Selective serotonin receptor inhibitor class of anti-depressant cause anorexia and weight loss.
• Amphetamine (CNS stimulant) have effect of decrease desire for food which lead to weight loss Child taking amphetamine shows doze dependent growth retardation.
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